Alcohol affects people differently, depending on their size, sex, body build, and metabolism. General effects are a feeling of warmth, flushed skin, impaired judgment, decreased inhibitions, muscular in coordination, slurred speech, and memory and comprehension loss. In states of extreme intoxication, vomiting is likely to occur, possibly accompanied by incontinence, poor respiration, a fall in blood pressure, and in cases of severe alcohol poisoning, coma and death.

Drinking heavily over a short period of time usually results in a "hangover" - headache, nausea, shakiness, and sometimes vomiting, beginning from 8 to 12 hours later. A hangover is due partly to poisoning by alcohol and other components of the drink, and partly to the body's reaction to withdrawal from alcohol.
Combining alcohol with other drugs can make the effects of these other drugs much stronger and more dangerous. Many accidental deaths have occurred after people have used alcohol combined with other drugs. Cannabis, tranquillizers, barbiturates and other sleeping pills, or antihistamines (in cold, cough, and allergy remedies) should not be taken with alcohol. Even a small amount of alcohol with any of these drugs can seriously impair a person's ability to drive a car.

People who drink on a regular basis become tolerant to many of the unpleasant effects of alcohol, and thus are able to drink more before suffering these effects. Yet even with increased consumption, many such drinkers don't appear intoxicated. Because they continue to work and socialize reasonably well, their deteriorating physical condition may go unrecognized by others until severe damage develops - or until they are hospitalized for other reasons and suddenly experience alcohol withdrawal symptoms.

Psychological dependence on alcohol may occur with regular use of even relatively moderate daily amounts. It may also occur in people who consume alcohol only under certain conditions, such as before and during social occasions. This form of dependence refers to a craving for alcohol's psychological effects, although not necessarily in amounts that produce serious intoxication. For psychologically dependent drinkers, the lack of alcohol tends to make them anxious and, in some cases, panicky.

Physical dependence occurs in consistently heavy drinkers. Since their bodies have adapted to the presence of alcohol, they suffer withdrawal symptoms if they suddenly stop drinking. Withdrawal symptoms range from jumpiness, sleeplessness, sweating, and poor appetite, to tremors (the "shakes"), convulsions. hallucinations. and sometimes death.
Alcohol abuse can take a negative toll on people's lives, fostering violence or a deterioration of personal relationships. Alcoholic behaviour can interfere with school or career goals and lead to unemployment.

Long term alcohol abuse poses a variety of health risks, such as as liver damage and an increased risk for heart disease. Fetal Alcohol Syndrome may result from a pregnant woman's drinking alcohol; this condition causes facial abnormalities in the child, as well as growth retardation and brain damage, which often is manifested by intellectual difficulties or behavioural problems